Successful healing of non-healing surgical wound based on the release of platelet-derived growth factors from single donor allogeneic platelet-RICH plasma with one freeze-thaw cycle: a case report after a 1-year follow-up

Abstract Background Non-healing surgical wounds is a risk in certain patients. Recently, allogenic plasma-rich-platelet (PRP) used such as regenerative treatment of different non-healing wounds. Purpose We explore the potential role using platelet-derived growth factors from single donor PRP, with freeze-thaw process, for scar ulcer. Methods have PRP preparation protocol that involved cycle centrifugation at mean speed 2400–2800 rpm blood taken an apheresis machine. Results To our knowledge, this first study (PDGF) apheresis, process. Four weeks after daily application al-PRP, ulcer progressed satisfactorily; six weeks, had healed. Conclusion concluded healing wound observed case, promising and suggests al-PRP might play treating ulcers. This must be confirmed future studies.